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Creators/Authors contains: "Foster, K.L."

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  1. ; ; ; ; ; ; ; (, Solid-State Sensor, Actuator, and Microsystems Workshop, Hilton Head, SC)
    We report the application of stress to biological cells at unprecedented strain (50%), strain rate (180,000 s-1), and throughput (1,800 cells/min) using a high-speed, high actuation force magnetically-driven MEMS chip. This device is uniquely suited to study the effects of impact on large populations of inherently heterogeneous cells, enabling statistical analysis that can elucidate the cell-level ramifications of Traumatic Brain Injury (TBI). To demonstrate the capabilities of the μHammer, we applied TBI-relevant strains and strain rates to human leukemic K562 cells then monitored their proliferation for 9 days. We observed significantly repressed proliferation of the hit cells compared to both the negative and sham controls, indicating success in applying sublethal cellular damage. 
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